arterial pressure — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11831	LDN-27219		Others
	LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.		Others
T30615	Bupicomide
	Bupicomide is a vasodilator that significantly reduces systolic, diastolic, and means arterial pressure, as well as peripheral vascular resistance.
T26841	BMS 182874	BMS182874,BMS-182874	Endothelin Receptor
	BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for ETA.BMS 182874 is able to reduce arterial pressure in a rat ...		Endothelin Receptor
T34146	Propanidid	FBA 1420,Epontol,Sombrevin,Fabontal,Fabantol	GABA Receptor
	Propanidid (Sombrevin) is a gamma-aminobutyric acid type A receptor (GABAA) agonist and a fast-acting intravenous anesthetic that lowers arterial blood pressure.		GABA Receptor
T9881	Benzoquinamide hydrochloride	3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride	Others
	Benzoquinamide hydrochloride (3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride) is an antiemetic agent and increases intra-arterial pressure due to the incre...		Others
T36506	Tempone	4-Oxo-tempo
	Tempone is an aminooxyalkane that acts as a free radical scavenger and reacts with reactive oxygen species (ROS). Intravenous Tempone reduces mean arterial pressure in spontaneously hypertensive rats.
T1462	Captopril	SQ 14225,SQ-14534,SA333	RAAS
	Captopril (SA333) is a potent and specific inhibitor of peptidyl-dipeptidase A. It blocks the conversion of angiotensin I to angiotensin II, a vasoconstrictor and important regulator of arterial blood pressure.		RAAS
T13604	CDDO-dhTFEA		Others , NF-κB , Nrf2
	CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expressi...		Others , NF-κB , Nrf2
TP1369L	[Sar9,Met(O2)11]-Substance P acetate	[Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base)	Neurokinin receptor
	[Sar9,Met(O2)11]-Substance P acetate is a tachykinin NK1 receptor selective agonist. [Sar9,Met(O2)11]-Substance P acetate is a selective tachykinin NK1 receptor agonist.[Sar9,Met(O2)11]-Substance P acetate and septide (1...		Neurokinin receptor
T0112L	Diltiazem	Diltiazem free base,Dilticard,CRD-401,CRD401,Dilzen,CRD 401
	Diltiazem is a non-dihydropyridine (non-DHP) calcium channel blocker that relaxes the smooth muscle in arterial walls, thus opening (dilating) arteries, allowing easier blood flow, and lowering blood pressure, and is use...
T73216	Gepefrine
	Gepefrine, an orally active pressor and sympathomimetic agent, enhances the initial orthostatic regulation of arterial pressure.
T25237	Chloracyzine	Chloroacizine,Chloroacizin,Chlorazicine,Chloroacyzin
	Chloracyzine can produce a decrease in myocardial oxygen consumption accompanied by a reduction in coronary blood flow preceded by transient coronary dilatation. It produced an insignificant increase in arterial pressure...
T36565	Adrenomedullin (13-52) (human) (trifluoroacetate salt)
	Adrenomedullin (13-52) is a truncated form of adrenomedullin (1-52) . It induces nitric oxide-dependent relaxation of and inhibits release of angiotensin II and endothelin-1 from isolated rat aorta. In vivo, adrenomedull...
TP1923	Elabela(19-32)	ELA-14 (human)
	Potent apelin (APJ) receptor agonist (Ki = 0.93 nM). Bioactive fragment of ELA-32. Activates Gαi1 pathway and β-arrestin-2 recruitment. Reduces arterial pressure in rat hearts. Active in vivo.
T81916	LPLRF-NH2
	LPLRF-NH2, an RFamide peptide, exhibits an anorexigenic effect, elevates arterial blood pressure, and alters brainstem neuronal electrical activity [1] [2] [3].
T76633	(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin
	(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin, a potent vasopressin V1 receptor (VP V1R) antagonist, significantly lowers mean arterial pressure (MAP) in rats [1].
T70654	Ciprokiren
	Ciprokiren is a renin inhibitor discovered by Roche. Ciprokinen inhibited human renin in a buffer and human plasma with an IC50 of 0.07 and 0.65 nmol/L, respectively. In animal models, acute and chronic administration of...
T82933	Auriculin A
	Auriculin A, a synthetic atrial natriuretic factor (ANF), exhibits hemodynamic properties by antagonizing renal vasoconstriction in dogs and affects arterial baroreflex regulation of heart rate, systemic blood pressure, ...
T14068	A-192621		Others
	A-192621 is a potent, nonpeptide, orally active and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. A-192621 promotes apoptosis in PASMCs and it also causes elevation of arteri...		Others
TP1369	[Sar9,Met(O2)11]-Substance P TFA(110880-55-2,free)	[Sar9,Met(O2)11]-Substance P TFA
	[Sar9,Met(O2)11]-Substance P TFA is a selective tachykinin NK1 receptor agonist.[Sar9,Met(O2)11]-Substance P and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and h...